0102030405
Cosmetic Grade Decarboxy Carnosine Hydrochloride (≥98%)
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Product Description
1. Mechanism of Action (MOA)
Decarboxy Carnosine Hydrochloride is a stabilized derivative of L-carnosine with enhanced bioavailability and cellular penetration. Its primary mechanisms include:
Advanced Glycation End-products (AGEs) Inhibition
Acts as a potent carbonyl quencher, neutralizing reactive dicarbonyl species (e.g., methylglyoxal, glyoxal) that drive protein cross-linking and AGEs formation.
Protects collagen and elastin fibers from glycation-induced stiffness and yellowing.
Mitochondrial Protection
Reduces glycative and oxidative stress in mitochondria, preserving cellular energy production and delaying senescence.
Anti-Inflammatory Activity
Suppresses NF-κB pathway activation and downstream pro-inflammatory cytokines (e.g., IL-6, TNF-α).
2. In Vitro Efficacy Data
AGEs Inhibition: 92% reduction in methylglyoxal-induced collagen glycation at 0.05 mM.
Carbonyl Quenching Capacity: 4.5-fold higher than L-carnosine in glycation simulation models.
Collagen Protection: 80% decrease in fluorescent AGEs formation in human dermal fibroblasts.
Cellular Viability: 40% reduction in ROS levels under glycative stress.
3. Clinical Results
Study Design: 8-week randomized trial on 50 subjects (35–60 years) using a cream containing 1.5% Decarboxy Carnosine HCl.
Key Outcomes:
Skin Elasticity: 21% improvement (cutometer R7 parameter).
Wrinkle Depth: 28% reduction in periocular wrinkles by 3D image analysis.
Skin Clarity: Significant decrease in yellowing (ΔITA° = +7.5).
Hydration: 18% increase in corneometer values.
Subject Feedback: 88% reported improved skin firmness and brightness.
Safety Profile
Non-irritating (HRIPT certified), non-comedogenic, and suitable for sensitive skin.
Formulation Compatibility
*Stable at pH 4.5–7.5.
*Compatible with antioxidants (vitamin C, E), niacinamide, hyaluronic acid, and most peptide blends.
*Avoid strong oxidizing/reducing agents and highly alkaline conditions (>pH 8.0).
*Compatible with antioxidants (vitamin C, E), niacinamide, hyaluronic acid, and most peptide blends.
*Avoid strong oxidizing/reducing agents and highly alkaline conditions (>pH 8.0).
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Recommended Usage & Dosage
Use Level: 1–3% in final product.
Optimal Dose: 1.5–2% for significant anti-glycation and anti-aging benefits.
Recommended Applications:
Anti-glycation serums and creams
Mature skin treatments
Brightening and radiance-boosting formulations
Preventive aging products
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Enhanced Bioavailability
Hydrochloride salt form improves skin penetration and stability.
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Potent Anti-Glycation
Superior carbonyl quenching vs. traditional carnosine.
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Multi-Modal Anti-Aging
Combats glycation, oxidation, and inflammation simultaneously.
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Clinically Validated
Proven efficacy in improving elasticity, wrinkles, and skin tone.
Storage
Store in a closed container at a dry place at room temperature.
Animal Testing
Not animal tested
Vegan
Does not contain animal-derived components
GMO
No data available